1. Introduce NSAIDS and side effects, think mostly about cardiovascular side effects. Cover what the direct effects of NSAIDs are – ie COX inhibitors. There is a big debate about whether NSAIDs are deleterious due to COX2 effects in the arteries. Paper attached indicates that the model is being rewritten.

2. What are the off target effects of NSAIDs? Could they have side effects due to non-COX mediated events? We started investigating via computational chemistry (previous paper sent) – cover this
3. Choice of nuclear receptors based on this paper (Zloh et al) – other nuclear receptors to investigate

4. Describe how antagonism of your nuclear receptor could be linked to CVD (estrogen and progesterone)

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Posted on May 23, 2016Author TutorCategories Question, Questions